1140-171 Elevated gene expression of asymmetric dimethylarginine-generating enzymes in atherosclerosis

Endothelium, asymmetric dimethylarginine, and atherosclerosis in chronic kidney disease.

Is asymmetric dimethylarginine a novel marker of atherosclerosis?

of Atherosclerosis? To the Editor: In their article, Miyazaki et al1 demonstrate a correlation between the plasma concentration of asymmetric dimethylarginine (ADMA) and carotid artery intima-media thickness in humans. In multivariate regression analyses, ADMA was the only significant predictor of carotid intima-media thickness besides age and impaired glucose tolerance. However, one critical f...

Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.

AIMS Coronary endothelial dysfunction (CED) precedes atherosclerosis and is associated with cardiovascular events. Both CED and erectile dysfunction (ED) are partly mediated by impairment in the nitric oxide pathway. ED is associated with established coronary atherosclerosis, but its relationship with early coronary atherosclerosis and CED is unknown. This study was designed to test the hypothe...

Asymmetric dimethylarginine and asthma.

ADMA, a product of protein degradation, is an endogenous nitric oxide synthase inhibitor that has been shown to be increased in mouse models of allergic airway inflammation and to be associated with airways hyperresponsiveness in these animals [2]. ADMA has also been reported to be increased in sputum samples [2] and exhaled breath condensates [3] from paediatric patients with asthma. Increased...

Cardiovascular effects of asymmetric dimethylarginine.

Asymmetric Dimethylarginine To the Editor: Kielstein et al1 describe the effects of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in humans in vivo but do not make reference to two previous human studies.2,3 In the original paper describing the presence of ADMA in human plasma and its accumulation in chronic renal failure, Vallance et al2 also described the...